A compensating and lipid-replenishing moisturizing cream, which compensates for the drying effects of drug treatments that dry out acne-prone skin. Thanks to a combination of targeted active ingredients: lipid-replenishing glycolol, and dextran sulphate, an active ingredient that calms irritation and reduces redness, this cream contributes to reconstituting the altered hydrolipidic film, nourishing and restoring skin comfort in order to facilitate the monitoring of drug treatments. In addition, its creamy, non-greasy texture is easy to spread and quickly absorbed.